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Advanced Ion Mobility Spectrometry

The Ion Mobility Spectrometry (IMS) is a separation technique based on interaction of ions with molecules of buffer gas in a weak homogenous electric field. Among others factors, the separation depends on the mass of the ions and their geometry. This allows separation of isomeric ions. The IMS is due to its compact design, high sensitivity and quick response a valuable instrument for volatile organic compounds (VOC) monitoring in various applications.

The Advanced Ion Mobility Spectrometer (AIMS) developed by MaSaTECH company offers resolution up to 70 FWHM, what is sufficient for separation of isomeric compounds. The big advantage of AIMS is its ability to work with atmospheric air as a buffer gas. This advantage reduces the operating costs to zero. The high sensitivity of IMS technique is in the MaSaTECH AIMS instrument improved by the corona discharge (CD) ionization source. Among the other advantages like non-radioactivity and higher ion yield generation, offers the CD selective reactant ions generations. The CD implemented in AIMS is able to generate O2- or NO3- reactant ions in negative polarity1,2 and H3O+ or NO+ in positive polarity3. The selective reactant ions generation increases the sensitivity and selectivity of instrument3. AIMS is the only commercially available instrument, which allows the selective reactant ions generation.

The biggest advantage of AIMS consists in its capillary sample inlet. The capillary sample inlet designed by MaSaTECH company allows the use of the AIMS not just for VOC detection. This inlet technique also enables to use the AIMS for analysis of surfaces and liquids. The surface analysis can be provided by laser diode module. This sampling technique is based on desorption of semi-volatiles or non-volatiles compounds from the surface. The desorbed compounds are subsequently analyzed by AIMS instrument4. The Surface Sampling Method is a suitable combination of high resolution, high sensitivity Thin Layer Chromatography with AIMS5. The interface of Liquid sampling module (LSM) allows simple analysis of liquids with AIMS6. This technique is based on the thermal spray of the liquid and the mixture of vapours, when droplets are directly injected to the reaction region of the IMS, where the chemical ionization of the sample occure. The technique was successfully tested for detection of explosives in different solvents, as well as for the analysis of amino acids and dipeptides.

The AIMS is able to operate in atmospheric and subatmospheric pressure. It is possible to control all parameters like the shutter grid pulse width and period, drift field intensity, aperture grid electric potential, temperature and many others. All parameters of AIMS can be setup by the user. The instrument can be used for industry applications as well as for laboratory research.


The desorption profiles of isometric β− blocker analyzed by Laser Desorption AIMS

References

[1] M. Sabo, J. Matúška, Š. Matejčík; 2011, Talanta, 85, 400-405
[2] M. Sabo, Y. Okuyama, M. Kučera, Š. Matejčík; 2013, International Journal of Mass Spectrometry, 334, 19-26
[3] M. Sabo, Š. Matejčík; 2013, Analyst 138, 6907-6912
[4] M. Sabo, M. Malásková, Š. Matejčík; 2014, Analyst, 139, 5112-5117
[5] V. Ilbeigi, M. Sabo, Y. Valadbeigi, S. Matejcik, M. Tabrizchi; Journal of Chromatography A, 1459, 145-151
[6] M.Sabo, M.Malásková, O.Harmathová, J.Hradski, M.Masár, B.Radjenovic, Š. Matejčík; 2015, Analytical Chemistry 87, 7389–7394

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